John Evans and Ed Major were on target for the hosts, but they were outgunned by Charlie Kille, Dean March and Ryan Knight for Saints.
Holmer Green went nap with Jamie West scoring a hat-trick in their 5-0 victory over Ardley United at Watchet Lane.
Longlevens scored an 85th minute winner from James Campbell to deny Ascot United the chance to go top of the table.
Royal Wootton Bassett Town won 2-1 at home against Flackwell Heath with goals from Rob Lincoln and TJ Bohane, Leius Sinclair having equalised.
Shrivenham could not repeat the midweek win when they played Abingdon United at Barrington Park.
An evenly-fought game which the visitors just shaded 2-1, despite a late rally by a Shrivenham side who were possibly suffering from their midweek exertions.
Sam Ockwell netted an 86th minute reply after Kyle Moss and Joe Green had given United the lead.
Windsor FC came away from Tuffley Rovers with a 6-3 victory, as braces from Malachi Thomas and Daniel Roberts, as well as goals from Rob Lazarczuk and Jack Hall, saw them to the three points.
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